A stress adaptation pathway Fountain Pen termed the integrated stress response has been suggested to be active in many cancers including prostate cancer (PCa).Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa both in vitro and in vivo, and is active in PCa pa
Non-local choice mismatch is one of the most important problems in the Internet-scale and service-based workflow ecosystems.The state-of-the-art method can solve it by generating adaptors to check deadlock-freeness based on a reachability graph.The states in the reachability graph give clues to re-design the composition.Deadlocks are resolved via a
This paper deals with the degradation of NO by photocatalytic oxidation using TiO2-based coatings.Tests are conducted at a laboratory scale through an experimental setup inspired from ISO 22197-1 standard.Various parameters are explored to evaluate their influence on photocatalysis efficiency: TiO2 dry matter content applied to the surface, nature
Introduction.Preservation of historical and cultural environment is one of the most important tasks nowadays.Nevertheless, a developing city requires the development of architectural and urban environment, which contributes to the emerging of modern objects in historical areas of the city, often discordant.The primary parameter that determines the
Modern scientists, determining the features of social movements, investigate the institutional environment, cultural and material flows, communicative practices, and conditions affecting the activities of the participants.In the course of multidirectional activity, movements create new "communicative meanings" and make new topicsrelevant in a certa